Search results for "mucous membrane pemphigoid"

showing 8 items of 8 documents

Effect of desquamative gingivitis on periodontal status: a pilot study

2009

OBJECTIVE: Desquamative gingivitis (DG) represents the gingival manifestation associated with several mucocutaneous disorders and systemic conditions. Little is known of whether or not DG could influence the onset or progression of plaque-related periodontitis. In this study, the potential impact of DG on plaque-related attachment loss and pocket formation has been evaluated. METHODS: A cross-sectional evaluation of 12 patients with DG [eight oral lichen planus (OLP), four mucous membrane pemphigoid (MMP)], never treated for DG lesions or plaque-related periodontitis, was carried out. Probing depth (PD), clinical attachment loss (CAL), fullmouth plaque (FMPS), and bleeding (FMBS) scores wer…

AdultMaleChi-Square DistributionPemphigoid Benign Mucous MembraneDental PlaquePilot ProjectsMiddle AgedOral HygieneGingivitisStatistics Nonparametricoral lichen planuCross-Sectional StudiesSettore MED/28 - Malattie Odontostomatologichedesquamative gingivitimucous membrane pemphigoidPeriodontal Attachment Lossperiodontal statuOdds RatioHumansPeriodontal PocketFemaleAgedLichen Planus Oral
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Reciprocal altered expression of E-cadherin and P-cadherin in mucous membrane pemphigoid.

2011

E- and P- cadherins are involved in the selective adhesion of epidermal cells. To gain insight into the role of cadherins on the acantholysis of keratinocytes and further investigate the pathogenesis of Mucous Membrane Pemphigoid, we examined the expression of P-cadherin and E-cadherin, in normal human oral mucosa, lesional and peri-lesional mucosa in MMP. Twenty-nine samples from paraffin-embedded specimens of MMP were used for the study. Five specimens of healthy oral mucosa were evaluated as control group. To evaluate the E- and P-Cadherin expression, a mean percentage of positive cells was determined from the percentage of positive cells derived from the analysis of 100 cells in ten ra…

AdultMalePathologymedicine.medical_specialtyPemphigoidmucous pemphigoidBlistering disease; E-cadherin; Mucous Membrane Pemphigoid; P-cadherin;Blistering diseaseImmunologySettore MED/50 - Scienze Tecniche Mediche ApplicatePemphigoid Benign Mucous MembraneMucous Membrane PemphigoidHuman skinBiologyP-cadherinPathogenesisDownregulation and upregulationSettore MED/28 - Malattie OdontostomatologichemedicineImmunology and AllergyHumansOral mucosaAgedPharmacologyAged 80 and overCadherinAcantholysismucous pemphigoid; cadherinMouth MucosaE-cadherinMiddle Agedmedicine.diseaseCadherinsEpitheliummedicine.anatomical_structurecadherinCase-Control StudiesFemaleInternational journal of immunopathology and pharmacology
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Number III Mucous membrane pemphigoid

2005

Mucous membrane pemphigoid (MMP) is a sub-epithelial vesiculobullous disorder. It is now quite evident that a number of sub-epithelial vesiculobullous disorders may produce similar clinical pictures, and also that a range of variants of MMP exist, with antibodies directed against various hemidesmosomal components or components of the epithelial basement membrane. The term immune-mediated sub-epithelial blistering diseases (IMSEBD) has therefore been used. Immunological differences may account for the significant differences in their clinical presentation and responses to therapy, but unfortunately data on this are few. The diagnosis and management of IMSEBD on clinical grounds alone is impo…

Basement membranemedicine.medical_specialtyPemphigoidmedicine.diagnostic_testbiologybusiness.industryMucous membraneGeneral MedicineDiseasemedicine.diseaseDermatologymedicine.anatomical_structureMucous membrane pemphigoidImmunologyBiopsybiology.proteinMedicineAntibodybusinessImmunostainingOral Diseases
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Describing the gingival involvement in a sample of 182 Italian predominantly oral mucous membrane pemphigoid patients: A retrospective series

2016

Background The oral cavity has been frequently described as the only site of involvement or as the first manifestation of mucous membrane pemphigoid (MMP), being the gingival tissues often involved, but usually this has been effusively detailed in limited case series. This is a retrospective evaluation of the gingival involvement in 182 Italian patients with oral MMP. Material and Methods The diagnosis of MMP was established by both clinical morphology and direct immunofluorescence finding. Patient information (age, gender, risk factors and medical status) and parameters of manifestation (lesions’ distribution, site and type) were detailed. Results The mean age was 62 years for women (n=137…

Clinical features; Gingival status; Mucous membrane pemphigoid; Surgery; Otorhinolaryngology; 2734; Pathology and Forensic Medicine; Dentistry (all)Malemedicine.medical_specialtyMucous membrane pemphigoidGingival status2734Pemphigoid Benign Mucous MembraneDentistryOral cavityOral mucous membrane pemphigoidPathology and Forensic Medicine030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineMedicineHumansGeneral DentistryDirect fluorescent antibodyAgedRetrospective StudiesOral Medicine and Pathologybusiness.industryResearchBenign Mucous MembraneMean ageRetrospective cohort studyClinical features030206 dentistryMiddle Aged:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseDermatologyOtorhinolaryngologyItalyMale patientUNESCO::CIENCIAS MÉDICASGingival DiseasesDentistry (all)SurgeryFemalebusinessOral medicinePemphigoidAged; Female; Gingival Diseases; Humans; Italy; Male; Middle Aged; Pemphigoid Benign Mucous Membrane; Retrospective StudiesGingival disease
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Periodontal clinical and microbiological data in desquamative gingivitis patients.

2013

Objectives: A series of patients affected by desquamative gingivitis (DG) was investigated in order to evaluate relation patterns among clinical parameters relevant to plaque induced periodontitis, periodontal microbiological data and the presence of DG lesions. Patients and methods: Eight oral lichen planus (OLP) and four mucous membrane pemphigoid (MMP) patients were examined. Periodontal measurements (performed at six sites per tooth on all teeth) included probing depth (PD), gingival recession (REC), clinical attachment loss (CAL) and full mouth plaque (FMPS) and bleeding (FMBS) scores; the presence and the exact location (site by site) of DG lesions were carefully recorded. Sub-gingiva…

MaleDesquamative gingivitiMucous membrane pemphigoidSettore MED/50 - Scienze Tecniche Mediche ApplicateDentistrySettore MED/28 - Malattie OdontostomatologicheMedicineHumansGeneral DentistryGingival recessionAgedPeriodontitisbiologybusiness.industryPeriodontal pathogensSignificant differenceAggregatibacter actinomycetemcomitansMiddle Agedmedicine.diseasebiology.organism_classificationGingivitisDesquamative gingivitisstomatognathic diseasesPeriodontal statuOral lichen planuClinical attachment lossMucous membrane pemphigoidOral lichen planusFemalemedicine.symptombusinessClinical oral investigations
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Immune-Mediated Desquamative Gingivitis and Optical Coherence Tomography Diagnostic Patterns: Clinical Implication from a Systematic Review

2021

Desquamative Gingivitis (DG) comprises heterogeneous clinical manifestations of numerous immune-mediated muco-cutaneous diseases. Optical Coherence Tomography (OCT) has been proposed as a valuable diagnostic support even if, to date, there are no standardized OCT-diagnostic patterns applicable to DGs. A systematic review was performed to detect existing data on in vivo OCT diagnostic patterns of the most common immune-mediated DGs (i.e., pemphigus vulgaris, mucous membrane pemphigoid and oral lichen planus). It has been found that OCT exhibits specific patterns that address the diagnosis of DG by pemphigus vulgaris (i.e., intraepithelial unilocular blister, reduced epithelial thickness, pre…

Medicine (General)medicine.medical_specialtyClinical Biochemistryoral mucous membrane pemphigoidR5-920Immune systemOptical coherence tomographyMedicineskin and connective tissue diseasesPathologicaloptical coherence tomographyintegumentary systemmedicine.diagnostic_testbusiness.industryBrief Reportoral pemphigus vulgarisPemphigus vulgarisOral pemphigus vulgarismedicine.diseaseDermatologydesquamative gingivitiseye diseasesDesquamative gingivitisstomatognathic diseasesMucous membrane pemphigoidDesquamative gingivitis Optical coherence tomography Oral mucous membrane pemphigoid Oral pemphigus vulgarisOral lichen planusbusinessDiagnostics
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In-vivo-Konfokalmikroskopie in der Diagnose des okulären Schleimhautpemphigoids

2015

Hintergrund: Fur die Prognose des okularen Schleimhautpemphigoids (mucous membrane pemphigoid, MMP) ist eine fruhe Diagnosesicherung essenziell. Allerdings wird die Sensitivitat des sog. diagnostischen Goldstandards, der direkten (DIF) bzw. indirekten Immunfluoreszenz (IIF) mit einer Spanne von 30–80 % sehr variabel angegeben. Zusatzlich birgt die dafur notwendige Bindehautbiopsie die Gefahr der Exazerbation. Ziel dieser Studie war es, zu ermitteln, ob die nicht invasive In-vivo-Konfokalmikroskopie zur Erkennung eines okularen Schleimhautpemphigoids beitragen kann. Patienten und Methoden: Die Konjunktiva von 10 Pemphigoidpatienten und 10 Kontrollprobanden wurden mithilfe des o. g. Verfahren…

Ophthalmologybusiness.industryMucous membrane pemphigoidIn vivo confocal microscopyMedicineImage enhancementbusinessMolecular biologyKlinische Monatsblätter für Augenheilkunde
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In vivo optical coherence tomography imaging in a case of mucous membrane pemphigoid and a negative Nikolsky's sign.

2017

There is currently a growing interest in new diagnostic tools of the oral cavity and mucosa which are non-invasive, repeatable and reliable. A diagnosis of a suspected, autoimmune pathology was made regarding a 57-year-old patient with desquamative gingivitis. However, a negative Nikolsky's sign did not seem to indicate a diagnosis of mucous membrane pemphigoid neither was there any indication as to the optimum location for an incisional biopsy. As an imaging method, the use of optical coherence tomography (OCT) has enabled the obtaining of tomographic (cross-sectional) scans of tissue. Such images are acquired prior to and after verifying Nikolsky's sign, thereby enabling the clinician to …

Pathologymedicine.medical_specialtyIncisional biopsyDystoninAdministration TopicalPemphigoid Benign Mucous MembraneDermatologyDiagnostic toolsEpithelium030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineOptical coherence tomographyIn vivomedicineHumansFluorescent Antibody Technique IndirectGlucocorticoidsAutoantibodiesClobetasolIndirect immunofluorescencemedicine.diagnostic_testbusiness.industryMouth Mucosa030206 dentistryGeneral MedicineMiddle Agedmedicine.diseaseGingivitisDesquamative gingivitisoptical coherence tomography mucous membrane pemphigoid Nikolsky's signNikolsky's signMucous membrane pemphigoidFemalemedicine.symptombusinessTomography Optical CoherenceThe Journal of dermatology
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